Species differences in blood-brain barrier transport of three PET radioligands with emphasis on P-glycoprotein transport
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چکیده
Affiliations: Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 751 24 Uppsala, Sweden (SS,MHU) Uppsala Imanet, GE Healthcare, Box 967, 751 85 Uppsala, Sweden (SS,ÖL) Uppsala Applied Science Lab, GEMS PET Systems, GE Healthcare, 752 28 Uppsala, Sweden (OR, BL) Neurobiology Research Unit, Department of Neurology, Copenhagen University Hospital building 9201, Blegdamsvej 9, 2100 Copenhagen, Denmark (MP, BRK, GMK) Department of Biochemistry and Organic Chemistry, Uppsala University, Box 599, 751 24 Uppsala, Sweden (BL) DMD Fast Forward. Published on December 1, 2008 as doi:10.1124/dmd.108.024745
منابع مشابه
Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport.
Species differences occur in the brain concentrations of drugs, but the reasons for these differences are not yet apparent. This study was designed to compare brain uptake of three radiolabeled P-glycoprotein (P-gp) substrates across species using positron emission tomography. Brain concentrations and brain-to-plasma ratios were compared; [(11)C]verapamil in rats, guinea pigs, and monkeys; [(11...
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Background The radiolabelled inhibitor of the multidrug efflux transporter P-glycoprotein (P-gp) [C]elacridar was developed as a positron emission tomography (PET) tracer to assess expression levels of P-gp at the blood-brain barrier (BBB) [1]. [C]Elacridar was shown to interact specifically with P-gp at the rodent BBB, but its brain PET signal was very low, which was possibly caused by transpo...
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تاریخ انتشار 2008